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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2014

Contributo in rivista

Tipo: Articolo in rivista

Titolo: C9, t11-Conjugated linoleic acid ameliorates steatosis by modulating mitochondrial uncoupling and Nrf2 pathway

Anno di pubblicazione: 2014

Formato: Cartaceo

Autori: Mollica M.P.; Trinchese G.; Cavaliere G.; De Filippo C.; Cocca E.; Gaita M.; Della-Gatta A.; Marano A.; Mazzarella G.; Bergamo P.

Affiliazioni autori: Dipartimento Delle Scienze Biologiche, Università Degli Studi di Napoli Federico II, Napoli, Italy; Institute of Biosciences and BioResources, National Research Council (CNR-IBBR), Napoli, Italy; Institute of Food Sciences, National Research Council (CNR-ISA), Avellino, Italy

Autori CNR:

  • PAOLO BERGAMO
  • ENNIO COCCA
  • GIUSEPPE MAZZARELLA

Lingua: inglese

Abstract: Oxidative stress, hepatic steatosis, and mitochondrial dysfunction are key pathophysiological features of nonalcoholic fatty liver disease. A conjugated linoleic acid (CLA) mixture of cis 9, trans 11 (9,11-CLA) and trans 10, cis 12 (10,12-CLA) isomers enhanced the antioxidant/detoxifying mechanism via the activation of nuclear factor E2-related factor-2 (Nrf2) and improved mitochondrial function, but less is known about the actions of specific isomers. The differential ability of individual CLA isomers to modulate these pathways was explored in Wistar rats fed for 4 weeks with a lard-based high-fat diet (L) or with control diet (CD), and, within each dietary treatment, two subgroups were daily administered with 9,11-CLA or 10,12-CLA (30 mg/ day). The 9,11-CLA, but not 10,12-CLA, supplementation to CD rats improves the GSH/GSSG ratio in the liver, mitochondrial functions, and Nrf2 activity. Histological examination reveals a reduction of steatosis in L-fed rats supplemented with both CLA isomers, but 9,11-CLA downregulated plasma concentrations of proinflammatory markers, mitochondrial dysfunction, and oxidative stress markers in liver more efficiently than in 10,12-CLA treatment. The present study demonstrates the higher protective effect of 9,11-CLA against diet-induced pro-oxidant and proinflammatory signs and suggests that these effects are determined, at least in part, by its ability to activate the Nrf2 pathway and to improve the mitochondrial functioning and biogenesis.-Mollica, M. P., G. Trinchese, G. Cavaliere, C. De Filippo, E. Cocca, M. Gaita, A. Della-Gatta, A. Marano, G. Mazzarella, and P. Bergamo. c 9, t 11-Conjugated linoleic acid ameliorates steatosis by modulating mitochondrial uncoupling and Nrf2 pathway. J. Lipid Res . 2014. 55: 837-849. Copyright © 2014 by the American Society for Biochemistry and Molecular Biology, Inc.

Lingua abstract: inglese

Pagine da: 837

Pagine a: 849

Rivista:

Journal of lipid research American Society for Biochemistry and Molecular Biology
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 0022-2275

Numero volume: 55

Numero fascicolo: 5

DOI: 10.1194/jlr.M044032

Stato della pubblicazione: Published version

Indicizzato da: Scopus [2-s2.0-84899544534]

Parole chiave:

  • Fatty acids
  • Mitochondrial efficiency
  • Nuclear factor E2-related factor-2

URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84899544534&partnerID=q2rCbXpz

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