Home |  English version |  Mappa |  Commenti |  Sondaggio |  Staff |  Contattaci Cerca nel sito  
Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2014

Contributo in rivista

Tipo: Articolo in rivista

Titolo: A whole-grain cereal-based diet lowers postprandial plasma insulin and triglyceride levels in individuals with metabolic syndrome

Anno di pubblicazione: 2014

Formato: Elettronico

Autori: Giacco R.; Costabile G.; Della Pepa G.; Anniballi G.; Griffo E.; Mangione A.; Cipriano P.; Viscovo D.; Clemente G.; Landberg R.; Pacini G.; Rivellese A.A.; Riccardi G.

Affiliazioni autori: Institute of Food Science, National Research Council, Via Roma 64, 83100 Avellino, Italy; Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy; Department of Food Science, BioCentre, Swedish University of Agricultural Sciences, Uppsala, Sweden; Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy

Autori CNR:

  • GENNARO CLEMENTE
  • ROSALBA GIACCO
  • GIOVANNI PACINI

Lingua: inglese

Abstract: Background and aim: Until recently, very few intervention studies have investigated the effects of whole-grain cereals on postprandial glucose, insulin and lipid metabolism, and the existing studies have provided mixed results. The objective of this study was to evaluate the effects of a 12-week intervention with either a whole-grain-based or a refined cereal-based diet on postprandial glucose, insulin and lipid metabolism in individuals with metabolic syndrome. Methods and results: Sixty-one men and women age range 40-65 years, with the metabolic syndrome were recruited to participate in this study using a parallel group design. After a 4-week run-in period, participants were randomly assigned to a 12-week diet based on whole-grain products (whole-grain group) or refined cereal products (control group). Blood samples were taken at the beginning and end of the intervention, both fasting and 3 h after a lunch, to measure biochemical parameters. Generalized linear model (GLM) was used for between-group comparisons. Overall, 26 participants in the control group and 28 in the whole-grain group completed the dietary intervention. Drop-outs (five in the control and two in the whole-grain group) did not affect randomization. After 12 weeks, postprandial insulin and triglyceride responses (evaluated as average change 2 and 3 h after the meal, respectively) decreased by 29% and 43%, respectively, in the whole-grain group compared to the run-in period. Postprandial insulin and triglyceride responses were significantly lower at the end of the intervention in the whole-grain group compared to the control group (p = 0.04 and p = 0.05; respectively) whereas there was no change in postprandial response of glucose and other parameters evaluated. Conclusions: A twelve week whole-grain cereal-based diet, compared to refined cereals, reduced postprandial insulin and triglycerides responses. This finding may have implications for type 2 diabetes risk and cardiovascular disease. © 2014 Elsevier B.V.

Lingua abstract: inglese

Pagine da: 837

Pagine a: 844

Rivista:

NMCD. Nutrition Metabolism and Cardiovascular Diseases Medikal Press.
Paese di pubblicazione: Italia
Lingua: inglese
ISSN: 1590-3729

Numero volume: 24

Numero fascicolo: 8

DOI: 10.1016/j.numecd.2014.01.007

Referee: Sì: Internazionale

Indicizzato da: Scopus [2-s2.0-84904760558]

Parole chiave:

  • Cereal fiber
  • Glucose metabolism
  • Insulin metabolism
  • Lipids
  • Whole-grains

URL: http://www.ncbi.nlm.nih.gov/pubmed/24598599

Strutture CNR:

Moduli:

Allegati: A whole-grain cereal-based diet lowers postprandial plasma insulin and triglyceride levels in individuals with metabolic syndrome (application/pdf)

 
Torna indietro Richiedi modifiche Invia per email Stampa
Home Il CNR  |  I servizi News |   Eventi | Istituti |  Focus