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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2013

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line

Anno di pubblicazione: 2013

Formato: Cartaceo

Autori: Tedesco, I; Russo, M; Bilotto, S; Spagnuolo, C; Scognamiglio, A; Palumbo, R; Nappo, A; Iacomino, G; Moio, L; Russo, GL

Affiliazioni autori: CNR, Ist Sci Alimentaz, I-83100 Avellino, Italy, Univ Naples Federico II, Dipartimento Sci Alimenti, I-80055 Portici, NA, Italy

Autori CNR:


Lingua: inglese

Abstract: Until recently, the supposed preventive effects of red wine against cardiovascular diseases, the so-called "French Paradox", has been associated to its antioxidant properties. The interest in the anticancer capacity of polyphenols present in red wine strongly increased consequently to the enormous number of studies on resveratrol. In this study, using lyophilized red wine, we present evidence that its anticancer effect in a cellular model is mediated by apoptotic and autophagic cell death. Using a human osteosarcoma cell line, U2Os, we found that the lyophilized red wine was cytotoxic in a dose-dependent manner with a maximum effect in the range of 100-200 mu g/ml equivalents of gallic acid. A mixed phenotype of types I/II cell death was evidenced by means of specific assays following treatment of U2Os with lyophilized red wine, e.g., autophagy and apoptosis. We found that cell death induced by lyophilized red wine proceeded through a mechanism independent from its anti-oxidant activity and involving the inhibition of PI3K/Akt kinase signaling. Considering the relative low concentration of each single bioactive compound in lyophilized red wine, our study suggests the activation of synergistic mechanism able to inhibit growth in malignant cells.

Lingua abstract: inglese

Pagine da: 377

Pagine a: 384


Food and chemical toxicology Pergamon,
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 0278-6915

Numero volume: 0278-6915

DOI: 10.1016/j.fct.2013.07.078

Referee: Sì: Internazionale

Indicizzato da: ISI Web of Science (WOS) [000325231700045]

Parole chiave:

  • Red wine; Polyphenols; Apoptosis; Autophagy; U2Os cell line

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