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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2012

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Dietary polyphenols in cancer prevention: The example of the flavonoid quercetin in leukemia

Anno di pubblicazione: 2012

Formato: Elettronico Cartaceo

Autori: Spagnuolo, C., Russo, M., Bilotto, S., Tedesco, I., Laratta, B., Russo, G.L.

Affiliazioni autori: Istituto di Scienze dell'Alimentazione, Consiglio Nazionale delle Ricerche, Avellino, Italy; Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Pozzuoli (Napoli), Italy

Autori CNR:

  • STEFANIA BILOTTO
  • BRUNA LARATTA
  • GIAN LUIGI RUSSO
  • MARIA RUSSO
  • CARMELA SPAGNUOLO
  • IDOLO TEDESCO

Lingua: inglese

Abstract: Increased consumption of fruit and vegetables can represent an easy strategy to significantly reduce the incidence of cancer. We recently demonstrated that the flavonoid quercetin, naturally present in the diet and belonging to the class of phytochemicals, is able to sensitize several leukemia cell lines and B cells isolated from patients affected by chronic lymphocytic leukemia (B-CLL), in addition to apoptotic inducers (anti-CD95 and rTRAIL). Further, it potentiates the effect of fludarabine, a first-line chemotherapeutic drug used against CLL. The proapoptotic activity of quercetin in cell lines and B-CLL is related to the expression and activity of Mcl-1-antiapoptotic proteins belonging to the Bcl-2 family. Quercetin downregulates Mcl-1 mRNA and protein levels acting on mRNA stability and protein degradation. Considering the low toxicity of the flavonoids toward normal peripheral blood cells, our experimental results are in favor of a potential use of quercetin in adjuvant chemotherapy in CLL or other types of cancer. © 2012 New York Academy of Sciences.

Lingua abstract: inglese

Pagine da: 95

Pagine a: 103

Pagine totali: 9

Rivista:

Annals of the New York Academy of Sciences New York Academy of Sciences.
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 0077-8923

Numero volume: 1259

Numero fascicolo: 1

DOI: 10.1111/j.1749-6632.2012.06599.x

Referee: Sì: Internazionale

Indicizzato da:

  • Scopus [2-s2.0-84863514720]
  • PubMed [22758641]

Parole chiave:

  • antineoplastic agent
  • Fas antigen
  • fludarabine
  • messenger RNA
  • polyphenol
  • protein bcl 2
  • protein mcl 1
  • quercetin
  • recombinant tumor necrosis factor related apoptosis inducing ligand
  • tumor necrosis factor related apoptosis inducing ligand
  • acute granulocytic leukemia
  • acute lymphocytic leukemia
  • adjuvant therapy
  • antiproliferative activity
  • apoptosis
  • article
  • B lymphocyte
  • cancer prevention
  • chronic lymphatic leukemia
  • cytotoxicity
  • drug bioavailability
  • drug metabolism
  • drug uptake
  • human
  • leukemia cell line
  • nephrotoxicity
  • peripheral blood mononuclear cell
  • protein degradation
  • protein expression
  • RNA stability
  • Animals
  • Antineoplastic Agents
  • Phytogenic
  • Chemotherapy
  • Adjuvant
  • Diet
  • Flavonoids
  • Humans
  • Leukemia
  • Models
  • Biological
  • Neoplasms
  • Polyphenols
  • Quercetin

URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84863514720&partnerID=40&md5=900171233fa83e346564df2a47d0c1df

Altre informazioni: cited By (since 1996)4

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