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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2012

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Effects of some endocrine disruptors on cell cycle progression and murine dendritic cell differentiation

Anno di pubblicazione: 2012

Formato: Cartaceo

Autori: Pisapia, L., Del Pozzo, G., Barba, P., Caputo, L., Mita, L., Viggiano, E., Russo, G.L., Nicolucci, C., Rossi, S., Bencivenga, U., Mita, D.G., Diano, N.

Affiliazioni autori: Institute of Genetics and Biophysics of CNR, Naples, Italy; National Institute of Biostructures and Biosystems (INBB), Rome, Italy; Department of Experimental Medicine, Second University of Naples, Naples, Italy; Institute of Food Sciences of CNR, Avellino, Italy

Autori CNR:

  • PASQUALE BARBA
  • UMBERTO BENCIVENGA
  • GIOVANNA DEL POZZO
  • NADIA DIANO
  • DAMIANO GUSTAVO MITA
  • CARLA NICOLUCCI
  • LAURA PISAPIA
  • GIAN LUIGI RUSSO

Lingua: inglese

Abstract: Endocrine disruptor chemicals (EDCs), which are predominantly present in the environment, are able to mimic or antagonise the biological activity of hormones primarily through the interaction with specific receptors. The main consequences are adverse effects on the growth and development of reproductive organs, the induction of cancer and effects on neuronal differentiation. In this study, we investigated the ability of certain EDCs, Bisphenol A (BPA), Bisphenol B (BPB), Bisphenol F (BPF), 4-n Nonylphenol (NP) and Octylphenol (OP), belonging to a homogeneous group of phenol origin, to interfere with specific cellular processes, namely, proliferation, by using MCF-7 breast carcinoma cells, and differentiation, by using murine bone marrow dendritic cells. We correlated the data on cell growth with the stimulation of cell cycle progression, which could become a step in the development of cancer, and we established a proliferation ranking between the tested EDCs: NP > BPA > OP > BPB > BPF. In addition, we investigated the ability of NP, BPA and OP to induce the differentiation of dendritic cells, the powerful antigen-presenting cells of the immune system. The differentiation and activation of these cells could affect a well-regulated immune response and determine an allergic sensitisation. We found that BPA and NP were active in determining differentiation. © 2012 Elsevier Inc.

Lingua abstract: inglese

Pagine da: 54

Pagine a: 63

Pagine totali: 10

Rivista:

General and comparative endocrinology Academic Press.
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 0016-6480

Numero volume: 178

Numero fascicolo: 1

DOI: 10.1016/j.ygcen.2012.04.005

Referee: Sì: Internazionale

Indicizzato da: Scopus [2-s2.0-84860572907]

Parole chiave:

  • 4 nonylphenol
  • 4
  • 4' isopropylidenediphenol
  • bisphenol B
  • bisphenol f
  • endocrine disruptor
  • octylphenol
  • unclassified drug
  • animal cell
  • article
  • cell cycle progression
  • cell differentiation
  • cell growth
  • cell proliferation
  • cell strain MCF 7
  • controlled study
  • dendritic cell
  • estrogen activity
  • growth rate
  • mouse
  • nonhuman
  • priority journal
  • Animals
  • Cell Cycle
  • Cell Differentiation
  • Cell Line
  • Tumor
  • Cells
  • Cultured
  • Dendritic Cells
  • Endocrine Disruptors
  • Female
  • Humans
  • Mice
  • Mice
  • Inbred C57BL
  • Phenols

URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84860572907&partnerID=40&md5=f3eae92465284fe6488230df0e5971dc

Altre informazioni: cited By (since 1996)3

Strutture CNR:

Moduli:

Allegati: Effects of some endocrine disruptors on cell cycle progression and murine dendritic cell differentiation (application/pdf)

 
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