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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2013

Contributo in rivista

Tipo: Articolo in rivista

Titolo: AMP-activated protein kinase: A target for old drugs against diabetes and cancer

Anno di pubblicazione: 2013

Formato: Elettronico Cartaceo

Autori: Russo, G.L., Russo, M., Ungaro, P.

Affiliazioni autori: Institute of Food Sciences, National Research Council, 83100 Avellino, Italy; Institute of Experimental Endocrinology and Oncology, National Research Council, 80131 Naples, Italy

Autori CNR:

  • GIAN LUIGI RUSSO
  • MARIA RUSSO
  • PAOLA UNGARO

Lingua: inglese

Abstract: The AMP-activated protein kinase (AMPK) is considered a key checkpoint to ensure energy balance in both cells and organisms. AMPK is an ??? heterotrimer controlled by allosteric regulation by AMP, ADP and ATP, auto-inhibitory features and phosphorylation, with the threonine-172 phosphorylation on the catalytic ?-subunit by LKB1, CaMKK? or Tak1 being essential for its fully activation. AMPK acts as a protective response to energy stress in numerous systems, but it is also a key player in diabetes and related metabolic diseases and cancer. Pharmacological activation of AMPK by metformin or other compounds holds a considerable potential to reverse the metabolic abnormalities associated with type 2 diabetes. In cancer, correction of the dysregulated metabolic pathway LKB1/AMPK/mTORC1 can lower the Warburg effect, suggesting AMPK as a potential target for cancer prevention and/or treatment. In this commentary, we review recent findings that support the role and function of AMPK in normal and pathological conditions. We also discuss how the activation of AMPK by naturally occurring compounds could help to prevent the development of numerous chronic diseases contributing in such a way to the well-being of ageing population. © 2013 Elsevier Inc. All rights reserved.

Lingua abstract: inglese

Pagine da: 339

Pagine a: 350

Pagine totali: 12

Rivista:

Biochemical pharmacology Pergamon Press,
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 0006-2952

Numero volume: 86

Numero fascicolo: 3

DOI: 10.1016/j.bcp.2013.05.023

Referee: Sì: Internazionale

Indicizzato da:

  • Scopus [2-s2.0-84879375338]
  • PubMed [23747347]

Parole chiave:

  • AMP-activated protein kinase
  • Adenylate energy charge
  • Biguanides
  • Cancer
  • Diabetes
  • Energy metabolic stress
  • Natural compounds

URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84879375338&partnerID=40&md5=b6e919a8a04362b2b26c2a99db97b84e

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