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Contributo in rivista
Tipo: Articolo in rivista
Titolo: Past history of nephrolithiasis and incidence of hypertension in men: a reappraisal based on the results of the Olivetti Prospective Heart Study.
Anno di pubblicazione: 2001
Autori: Strazzullo P, Barba G, Vuotto P, Farinaro E, Siani A, Nunziata V, Galletti F, Mancini M, Cappuccio FP.
Affiliazioni autori: Department of Clinical and Experimental Medicine, Unit of Clinical Genetics and Pharmacology, Hypertension and Mineral Metabolism, Federico II University Medical School, Naples, Italy
Abstract: BACKGROUND: We have previously reported that in the Olivetti Prospective Heart Study cohort the incidence of nephrolithiasis was higher in hypertensive participants than in normotensive ones. As the time sequence and the mechanisms underlying the association between nephrolithiasis and hypertension remain controversial, we further tested the hypothesis that in a cohort of normotensive males a history of nephrolithiasis predicts the development of future hypertension. METHODS: The analysis was conducted in 381 male workers at Olivetti who were normotensive at the baseline examination and who were re-examined 8 years later. RESULTS: A past history of nephrolithiasis is associated with an increased risk of hypertension of 1.96 (95% CI=1.25-3.07) relative to subjects with a negative history, after adjusting for age. CONCLUSION: In this 8-year follow-up study, a history of nephrolithiasis resulted in an increased risk of developing hypertension in the future. As the reverse was also true, as previously reported, a clear-cut time sequence, as well as the mechanisms linking these two conditions, remain to be identified.
Lingua abstract: inglese
Pagine da: 2232
Pagine a: 2235
Pagine totali: 4
Nephrology, dialysis, transplantation
Oxford University Press
Numero volume: 16
Referee: Sė: Internazionale
Indicizzato da: PubMed 
Allegati: articolo pubblicato
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