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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2000

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Effects of sodium intake on the pressor and renal responses to nitric oxide synthesis inhibition in normotensive individuals with different sodium sensitivity.

Anno di pubblicazione: 2000

Formato: Cartaceo

Autori: Barba G, Vallance PJ, Strazzullo P, MacAllister RJ.

Affiliazioni autori: The Centre for Clinical Pharmacology and Therapeutics, University College London, UK; Istituto di Scienza dell'Alimentazione, CNR, Avellino, Italia

Autori CNR:


Lingua: inglese

Abstract: OBJECTIVE: The present study evaluated the role of nitric oxide (NO) in the systemic vascular and renal adaptation to changes in dietary sodium intake. DESIGN AND METHODS: Seven healthy normotensive male subjects were randomized to high or low sodium diets in a double blind crossover design (7 days on each diet). The NO synthesis inhibitor, NGmonomethyl-L-arginine (L-NMMA) was infused systemically (1.8 mg/kg over 30 min) at the end of each dietary period and its effects on blood pressure, renal plasma flow, glomerular filtration rate, urinary flow rate and sodium excretion were measured. RESULTS: Blood pressure increased in response to L-NMMA on a high sodium diet only (area under time curve percentage change in mean blood pressure, low sodium = -94.5 +/- 164.3; high sodium = 391.1 +/- 228.6; P < 0.05 low versus high). The increase in blood pressure was directly and significantly associated with the individual salt sensitivity, defined by the difference in systemic mean blood pressure between high and low sodium diets (r = 0.756; P < 0.05). L-NMMA also reduced renal plasma flow and urinary flow rate in subjects on high sodium diet. CONCLUSIONS: The data support a significant influence of endogenous NO in the systemic and renal vascular adaptation to a high sodium diet in normotensive men. In addition, the direct association between the individual sodium-sensitivity and the pressor response to L-NMMA suggests that there is increased dependence of vascular tone on NO in normotensive subjects whose blood pressure is more sodium sensitive.

Lingua abstract: inglese

Pagine da: 615

Pagine a: 621

Pagine totali: 7


Journal of hypertension Gower Medical,
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 0263-6352

Numero volume: 18

Numero fascicolo: 5

DOI: 10.1097/00004872-200018050-00015

Referee: Sė: Internazionale

Indicizzato da: PubMed [10826565]

Parole chiave:

  • Nitric oxide
  • L-NMMA
  • blood pressure
  • renal function
  • sodium
  • diet
  • sodium-dependent hypertension

Strutture CNR:


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