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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2000

Contributo in rivista

Tipo: Articolo in rivista

Titolo: N-Linked glycans of proteins from mitral valves of normal pigs and pigs affected by endocardiosis.

Anno di pubblicazione: 2000

Autori: Amoresano A, Amedeo S, D'andrea G, Siciliano R, Gagna C, Castagnaro M, Marino G, Guarda F.

Affiliazioni autori: a Ctro. Internazionale di Servizi, CNR-Università, Napoli, Italy b CEINGE S.C.R.L. Biotecnologie A., Napoli, Italy c Istituto Scienze dell'Alimentazione, CNR, Avellino, Italy d Intl. Mass Spectrom. Facilities Ctr., via Pansini 5, 80131 Napoli, Italy

Autori CNR:

  • ROSA ANNA SICILIANO

Lingua: inglese

Abstract: Endocardiosis, a degenerative and dystrophic process affecting cardiac valves and described in many mammalian species, is characterized by the accumulation of glycosaminoglycans, in particular hyaluronic acid, in the extracellular matrix. The glycoprotein patterns of pig mitral valves in normal animals and animals affected by endocardiosis were investigated. A different N-linked glycosylation pattern of glycoproteins was detected in affected valves compared with normal ones. In either normal or pathological species, the detected N-linked glycans were of the complex type. However, in samples from affected valves, sialic acid showed a prevalence of the ?2,6 linkage to the galactosyl residue, whereas in normal samples the most frequent linkage was of the ?2,3 type. In normal valves, the majority of complex oligosaccharides presented two outer branches with different degrees of fucosylation and sialylation, whereas in pathological samples we noted an increased number of glycans having up to four outer branches.

Lingua abstract: inglese

Pagine da: 1299

Pagine a: 1306

Pagine totali: 8

Rivista:

European journal of biochemistry Blackwell
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 0014-2956

Numero volume: 267

Numero fascicolo: 5

DOI: 10.1046/j.1432-1327.2000.01090.x

Referee: Sì: Internazionale

Indicizzato da: PubMed [10691966Document]

Parole chiave:

  • Endocardiosis
  • Glycoproteins
  • Mass spectrometry
  • Mitral valve
  • Pig

Strutture CNR:

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