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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in volume anno 2015

Contributo in volume

Tipo: Contributo in volume

Titolo: Natural Polymer Genomics: Phosphate-induced Self-Assembly of Polyamines

Anno di pubblicazione: 2015

Formato: Elettronico Cartaceo

: Capitolo

Autori: Picariello, Gianluca; Iacomino Giuseppe, D'Agostino Luciano

Affiliazioni autori: ISA-CNR

Autori CNR:

  • LUCIANO D'AGOSTINO
  • GIUSEPPE IACOMINO
  • GIANLUCA PICARIELLO

Lingua: inglese

Sintesi: Polyamines are linear polycations involved in many biological functions. We found that, in the cell nucleus, polyamines self-assemble with phosphate ions and generate three forms of compounds, the Nuclear Aggregates of Polyamines (NAPs) that, self-structuring in nanotube-like supramolecular polymers, wrap the genomic DNA. In an in vitro setting that mimics the nuclear environment, the assembly of polyamines and phosphates occurs within well-defined ratios, independent of the presence of the DNA template. Strict structural and functional analogies exist between the in vitro NAPs and their cellular homologues. Important aspects of DNA physiology, such as conformation, protection and packaging, have been connected to these compounds. Therefore, we propose their categorization as "natural" polymer genomics agents.

Lingua sintesi: eng

Pagine da: 5951

Pagine a: 5964

Titolo del volume: Encyclopedia of Biomedical Polymers & Polymeric Biomaterials

N. volume della serie/collana: 8

Curatore/i del volume: Mishra, M.

ISBN: 9781439898796

Edizione/Versione: 1st Ed

DOI: 10.1081/E-EBPP-120050590

Editore: Taylor & Francis Group, London (GBR)

Referee: Sì: Internazionale

Stato della pubblicazione: Published version

Parole chiave:

  • Polyamines; phosphates; Nuclear Aggregates of Polyamines; genomic DNA; supramolecular polymers; supramolecular chemistry; polymer genomics; self-assembly; molecular recognition.

URL: http://www.crcpress.com/product/isbn/9781439898796

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