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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2001

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Altered renal sodium handling and hypertension in men carrying the glucagon receptor gene (gly40ser) variant.

Anno di pubblicazione: 2001

Autori: Strazzullo P, Iacone R, Siani A, Barba G, Russo O, Russo P, D'Elia L, Farinaro E, Cappuccio FP

Affiliazioni autori: Department of Clinical and Experimental Medicine, Federico II University of Naples Medical School, Naples, Italy; Institute of Food Sciences, CNR, Avellino, Italy

Autori CNR:

  • GIANVINCENZO BARBA
  • PAOLA RUSSO
  • ALFONSO SIANI

Lingua: inglese

Abstract: A higher prevalence of hypertension has been associated with the G -->A/GT (Gly40Ser) polymorphism of the glucagon receptor gene (GCGR) in two population studies. As the mutated receptor is less responsive to glucagon, it has been speculated that the increased susceptibility to hypertension is due to deprivation of the recognized natriuretic effect of the hormone. To test this hypothesis we determined the frequency of the polymorphic variant and evaluated the segmental renal sodium handling by the clearances of uric acid and of exogenous lithium in the Olivetti Heart Study participants (n = 971). The polymorphic variant was present only in heterozygous form in 37 individuals (3.8%). After controlling for age and body mass index, the carriers of the variant were twice more likely to be hypertensive and almost three times more likely to be on antihypertensive treatment at the time of examination. Compared to participants carrying the wild type, those carrying the Gly40Ser allele had higher serum uric acid and lower fractional excretion of uric acid and exogenous lithium, independently of age, body mass, and current pharmacological treatment. We conclude that the Gly40Ser polymorphism of the GCGR gene is associated with higher risk of hypertension and with enhanced proximal tubular sodium reabsorption, a factor possibly contributing to hypertension in this group.

Lingua abstract: inglese

Pagine da: 574

Pagine a: 580

Rivista:

Journal of molecular medecine Elsevier
Paese di pubblicazione: Paesi Bassi
Lingua: inglese
ISSN: 0377-046X

Numero volume: 79

DOI: 10.1007/s001090100257

Referee: Sė: Internazionale

Indicizzato da:

  • ISI Web of Science (WOS) [000171816100006]
  • PubMed [11692154]

Parole chiave:

  • blood pressure
  • hypertension
  • glucagon
  • cAMP
  • natriuresis

Strutture CNR:

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