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Contributo in rivista
Tipo: Articolo in rivista
Titolo: Being Macrosomic at Birth is an Independent Predictor of Overweight in Children: Results from the IDEFICS Study.
Anno di pubblicazione: 2013
Autori: Sparano S, Ahrens W, De Henauw S, Marild S, Molnar D, Moreno LA, Suling M, Tornaritis M, Veidebaum T, Siani A, and Russo P.
Affiliazioni autori: S. Sparano A. Siani (&) P. Russo Epidemiology and Population Genetics, Institute of Food Sciences, National Research Council (CNR), Via Roma, 64, 83100 Avellino, Italy e-mail: firstname.lastname@example.org W. Ahrens M. Suling BIPS-Institute for Epidemiology and Prevention Research, Bremen, Germany W. Ahrens M. Suling Institute for Statistics, University of Bremen, Bremen, Germany S. De Henauw Department of Public Health, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium S. Marild Department of Paediatrics, Queen Silvia Children's Hospital, University of Gothenburg, Gothenburg, Sweden D. Molnar Department of Paediatrics, Medical Faculty, University of Pecs, Pecs, Hungary L. A. Moreno Growth, Exercise, Nutrition and Development Research Group, University of Zaragoza, Zaragoza, Spain M. Tornaritis Research and Education Institute of Child Health, Strovolos, Cyprus T. Veidebaum National Institute for Health Development, Tallin, Estonia
Abstract: Abstract Fetal macrosomia is a risk factor for the development of obesity late in childhood. We retrospectively evaluated the relationship between maternal conditions associated with fetal macrosomia and actual overweight/obesity in the European cohort of children participating in the IDEFICS study. Anthropometric variables, blood pressure and plasma lipids and glucose were measured. Socio-demographic data, medical history and perinatal factors, familiar and gestational history, maternal and/or gestational diabetes were assessed by a questionnaire. Variables of interest were reported for 10,468 children (M/F = 5,294/5,174; age 6.0 ± 1.8 years, M ± SD). The sample was divided in four groups according to child birth weight (BW) and maternal diabetes: (1) adequate for gestational age offspring (BW between the 10th and 90th percentiles for gestational age) of mothers without diabetes (AGA-ND); (2) adequate for gestational age offspring of mothers with diabetes (AGA-D); (3) macrosomic offspring (BW[90th percentile for gestational age) of mothers without diabetes (Macro-ND); (4) macrosomic offspring of mothers with diabetes (Macro-D). Children macrosomic at birth showed significantly higher actual values of body mass index, waist circumference, and sum of skinfold thickness. In both boys and girls, Macro-ND was an independent determinant of overweight/obesity, after the adjustment for confounders [Boys: OR = 1.7 95 % CI (1.3;2.2); Girls: OR = 1.6 95 % CI (1.3;2.0)], while Macro-D showed a significant association only in girls [OR = 2.6 95 % CI (1.1;6.4)]. Fetal macrosomia, also in the absence of maternal/gestational diabetes, is independently associated with the development of overweight/ obesity during childhood. Improving the understanding of fetal programming will contribute to the early prevention of childhood overweight/obesity.
Lingua abstract: inglese
Pagine da: 1373
Pagine a: 1381
Maternal and child health journal
Numero volume: 17
Referee: Ś: Internazionale
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