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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2011

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Potassium intake, stroke, and cardiovascular disease a meta-analysis of prospective studies.

Anno di pubblicazione: 2011

Formato: Cartaceo

Autori: D'Elia L, Barba G, Cappuccio FP, Strazzullo P.

Affiliazioni autori: Dipartimento di Medicina Clinica e Sperimentale, UniversitÓ di Napoli "Federico II"; Istituto di Scienze del'Alimentazione, CNR, Avellino; University of Coventry, UK

Autori CNR:

  • GIANVINCENZO BARBA

Lingua: inglese

Abstract: OBJECTIVES: The objective of this study was to assess the relation between the level of habitual potassium intake and the incidence of cardiovascular disease (CVD). BACKGROUND: Prospective cohort studies have evaluated the relationship between habitual potassium intake and incidence of vascular disease, but their results have not been not entirely consistent. METHODS: We performed a systematic search for prospective studies published, without language restrictions (1966 to December 2009). Criteria for inclusion were prospective adult population study, assessment of baseline potassium intake, assessment of vascular events as outcome, and follow-up of at least 4 years. For each study, relative risks (RRs) and 95% confidence intervals (CIs) were extracted and pooled using a random-effect model, weighted for the inverse of the variance. Heterogeneity, publication bias, subgroup, and meta-regression analyses were performed. RESULTS: Eleven studies were identified, providing 15 cohort samples that included 247,510 male and female participants (follow-up 5 to 19 years), 7,066 strokes, 3,058 coronary heart disease (CHD) events, and 2,497 total CVD events. Potassium intake was assessed by 24-h dietary recall (n = 2), food frequency questionnaire (n = 6), or 24-h urinary excretion (n = 3). In the pooled analysis, a 1.64-g (42 mmol) per day higher potassium intake was associated with a 21% lower risk of stroke (RR: 0.79; 95% CI: 0.68 to 0.90; p = 0.0007), with a trend toward lower risk of CHD and total CVD that attained statistical significance after the exclusion of a single cohort, based on sensitivity analysis (RR: 0.93; 95% CI: 0.87 to 0.99; p = 0.03 and RR: 0.74; 95% CI: 0.60 to 0.91; p = 0.0037). CONCLUSIONS: Higher dietary potassium intake is associated with lower rates of stroke and might also reduce the risk of CHD and total CVD. These results support recommendations for higher consumption of potassium-rich foods to prevent vascular diseases.

Lingua abstract: inglese

Pagine da: 1210

Pagine a: 1219

Pagine totali: 10

Rivista:

JACC Ukra´ns'kij medicnij výsnik
Paese di pubblicazione: Ucraina
Lingua: multilingue
ISSN: 2071-0496

Numero volume: 57

Numero fascicolo: 10

DOI: 10.1016/j.jacc.2010.09.070

Referee: Sý: Internazionale

Indicizzato da: PubMed [21371638]

Strutture CNR:

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