Home |  English version |  Mappa |  Commenti |  Sondaggio |  Staff |  Contattaci Cerca nel sito  
Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2012

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Immunogenicity of Monococcum wheat in Celiac Patients.

Anno di pubblicazione: 2012

Formato: Elettronico

Autori: Carmen Gianfrani, Maria Maglio, Vera Rotondi Aufiero, Alessandra Camarca, Immacolata Vocca, Gaetano Iaquinto, Nicola Giardullo, Norberto Pogna, Riccardo Troncone, Salvatore Auricchio and Giuseppe Mazzarella

Affiliazioni autori: From the Institute of Food Sciences, Immunobiology, National Council Research, Avellino, Italy (CG, VRA, AC, IV, and GM); the Department of Paediatrics and European Laboratory for the Investigation of Food-Induced Diseases, University Federico II, Naples, Italy (MM, RT, and SA); the Gastroenterology and Digestive Endoscopy Service, San G Moscati Hospital, Avellino, Italy (NG and GI); the Unit for Cereal Quality, CRAQCE, Rome, Italy (NP); and the King Saud University, Riyadh, Saudi Arabia (RT).

Autori CNR:


Lingua: inglese

Abstract: Background: Research is intense to find wheat of low or null toxicity for patients with celiac disease (CD). Among candidates, there are diploid wheat species. Objective: We compared the immunological properties of 2 lines of diploid monococcum wheat (Triticum monococcum ssp. monococcum), Monlis and ID331, with those of common wheat (Triticum aestivum). Design: Interferon-g production and the proliferation of intestinal gliadin-specific T cell lines and clones were measured as evidence of T cell activation by peptic and tryptic (PT) digests of gliadins from 2 monococcum lines. Furthermore, organ cultures of jejunal biopsies from 28 CD patients were set up to assess the effects of PT gliadin on innate and adaptive immune response by using immunohistochemistry. Results: Monlis and ID331 induced interferon-g production and proliferation in celiac mucosal T cells. In organ cultures, Monlis PT digest induced a significant increase of IL-15 epithelial expression and crypt enterocyte proliferation, whereas ID331 had no effect. Both monococcum lines caused intraepithelial T cell infiltration and lamina propria T cell activation. Conclusions: Our data show that the monococcum lines Monlis and ID331 activate the CD T cell response and suggest that these lines are toxic for celiac patients. However, ID331 is likely to be less effective in inducing CD because of its inability to activate the innate immune pathways.

Lingua abstract: inglese

Pagine da: 1338

Pagine a: 1344

Pagine totali: 7


The American journal of clinical nutrition Journal of Clinical Nutrition,
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 0002-9165

Numero volume: 96

Stato della pubblicazione: Published version

Parole chiave:

  • celiac
  • Triticum monococcum
  • innate immunity

Strutture CNR:


Torna indietro Richiedi modifiche Invia per email Stampa
Home Il CNR  |  I servizi News |   Eventi | Istituti |  Focus