Home |  English version |  Mappa |  Commenti |  Sondaggio |  Staff |  Contattaci Cerca nel sito  
Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2012

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Diet supplementation with donkey milk up-regulates liver mitochondrial uncoupling, reduces energy efficiency and improves anti-oxidant and anti-inflammatory defences in rats.

Anno di pubblicazione: 2012

Formato: Cartaceo

Autori: Lionetti L, Cavaliere G, Bergamo P, Trinchese G, De Filippo C, Gifuni G, Gaita M, Pignalosa A, Putti R, Di Palo R, Barletta A, Mollica MP

Affiliazioni autori: Università Federico II di Napoli

Autori CNR:

  • PAOLO BERGAMO

Lingua: inglese

Abstract: Dietary PUFA, mainly those of the n-3 family, are known to play essential roles in the maintenance of energy balance and in the reduction of body fat deposition through the up regulation of mitochondrial uncoupling that is the main source of reactive oxygen species. We hypothesized that rat supplementation with raw donkey's milk (DM), characterized by low-fat content and higher n3:n6 ratio, may affect energy balance, lipid metabolism, and pro oxidant status as compared to animals treated with cow's milk. In the present study, the effects of drinking raw DM (for 4 weeks) on energy balance, lipid metabolism, antiinflammatory, and antioxidant/ detoxifying defences was compared to that produced by rat intake of an iso-energetic amount of raw cow's milk. The hypolipidemic effect produced by DM paralleled with the enhanced mitochondrial activity/proton leakage and with the increased activity or expression of mitochondrial markers namely, carnitine palmitoyl transferase and uncoupling protein 2. The association of decreased energy efficiency with reduced proinflammatory signs (TNF- and LPS levels) with the significant increase antioxidant (total thiols) and detoxifying enzyme activities (glutathione-S-transferase NADH quinone oxidoreductase) in DM-treated animals, indicated that beneficial effects were attributable, at least in part, to the activation of nuclear factor 2 erythroid-related factor 2 pathway.

Lingua abstract: inglese

Pagine da: 1596

Pagine a: 1600

Pagine totali: 5

Rivista:

Molecular nutrition & food research Wiley-VCH-Verl..
Paese di pubblicazione: Germania
Lingua: inglese
ISSN: 1613-4125

Numero volume: 56

Numero fascicolo: 10

DOI: 10.1002/mnfr.201200160

Referee: Sì: Internazionale

Stato della pubblicazione: Published version

Indicizzato da: PubMed [22930490]

Parole chiave:

  • Donkey milk / Energy expenditure / Inflammatory parameters / Mitochondrial efficiency / Redox status

Strutture CNR:

Moduli:

 
Torna indietro Richiedi modifiche Invia per email Stampa
Home Il CNR  |  I servizi News |   Eventi | Istituti |  Focus