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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2012

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Reintroduction of gluten following flour transamidation in adult celiac patients: a randomized, controlled clinical study.

Anno di pubblicazione: 2012

Formato: Cartaceo

Autori: Mazzarella G, Salvati VM, Iaquinto G, Stefanile R, Capobianco F, Luongo D, Bergamo P, Maurano F, Giardullo N, Malamisura B, Rossi M.

Affiliazioni autori: a Institute of Food Sciences, CNR, 83100 Avellino, Italy b Center for Coeliac Disease, S. Maria dell'Olmo Hospital, 84013 Cava de' Tirreni Salerno, Italy c Gastroenterology Department, San G. Moscati Hospital, 83100 Avellino, Italy d IPALC Research Development, 83040 Frigento, AV, Italy

Autori CNR:

  • PAOLO BERGAMO
  • DIOMIRA LUONGO
  • FRANCESCO MAURANO
  • GIUSEPPE MAZZARELLA
  • MAURO ROSSI

Abstract: A lifelong gluten-free diet (GFD) is mandatory for celiac disease (CD) but has poor compliance, justifying novel strategies. We found that wheat flour transamidation inhibited IFN- secretion by intestinal T cells from CD patients. Herein, the primary endpoint was to evaluate the ability of transamidated gluten to maintain GFD CD patients in clinical remission. Secondary endpoints were efficacy in prevention of the inflammatory response and safety at the kidney level, where reaction products are metabolized. In a randomized single blinded, controlled 90-day trial, 47 GFD CD patients received 3.7g/day of gluten from nontransamidated (12) or transamidated (35) flour. On day 15, 75 and 37 of patients in the control and experimental groups, respectively, showed clinical relapse (P = 0.04) whereas intestinal permeability was mainly altered in the control group (50 versus 20, P = 0.06). On day 90, 0 controls and 14 patients in the experimental group completed the challenge with no variation of antitransglutaminase IgA (P = 0.63), Marsh-Oberhuber grading (P = 0.08), or intestinal IFN-? mRNA (P <= 0.05). Creatinine clearance did not vary after 90 days of treatment (P = 0.46). In conclusion, transamidated gluten reduced the number of clinical relapses in challenged patients with no changes of baseline values for serological/mucosal CD markers and an unaltered kidney function

Lingua abstract: inglese

Rivista:

Clinical & developmental immunology Taylor & Francis Health Sciences,
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 1740-2522

Numero volume: 2012

DOI: 10.1155/2012/329150

Referee: Sì: Internazionale

Indicizzato da: PubMed [22899947]

Parole chiave:

  • albumin; creatinine; gamma interferon; gliadin; globulin; gluten; glutenin; immunoglobulin A antibody; messenger RNA; protein glutamine gamma glutamyltransferase antibody; transamidated gluten; unclassified drug

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