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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2013

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Release kinetics of Calcium and Quercetin from chewing gum as a novel antiplaque and antimicrobial device

Anno di pubblicazione: 2013

Formato: Elettronico Cartaceo

Autori: Di Stasio M, Nazzaro M, Volpe MG

Affiliazioni autori: Consiglio Nazionale delle Ricerche - Istituto di Scienze dell'Alimentazione, Via Roma 64, 83100 Avellino, Italy

Autori CNR:


Lingua: inglese

Abstract: There is a growing interest in the use of anticariogenic and antimicrobial agents to prevent demineralization and promote remineralization of dental enamel for the prevention of oral diseases. The purpose of this study was to developa novel chewing-system containing as Casein-Phosphopeptides-Amorphous-Calcium-Phosphate (CPP-ACP) as Quercetin (Qt) and evaluate their release using in vitro and in vivo experiments. In vitro and in vivo experimental protocols were designed to test the percentages of Ca from CPP-ACP and Qt released with time and their delivery rate from a chewinggum. The in vitro experiments were performed using a specifically designed chewing apparatus to test the release of Ca and Qt in artificial saliva in function of chewed time, while the in vivo experiments required a chew-out method with volunteers and the residual CPP-ACP and Qt present in the chewed gums was analyzed. This study demonstrated that both CPP-ACP'Ca and Qt were released during chewing although CPP-ACP'Ca was released from the chewing gum in a slower and more controlled manner than Qt. They were also both effectively retained in the oral cavity for all the investigated chewing time and according to their monitored release concentrations they were able to serve as a novel antiplaque agent. This research concludes that both drugs were efficiently released during the mastication process to fully exploit their anti-carious activity.

Lingua abstract: inglese

Pagine da: 261

Pagine a: 267

Pagine totali: 7


Current drug delivery Bentham Science Publishers
Paese di pubblicazione: Paesi Bassi
Lingua: inglese
ISSN: 1567-2018

Numero volume: 10

Numero fascicolo: 3

DOI: 10.2174/1567201811310030002

Referee: Ś: Internazionale

Stato della pubblicazione: Published version

Indicizzato da:

  • PubMed [23033929]
  • ISI Web of Science (WOS) [000319337400002]

Parole chiave:

  • Antioxidants
  • Casein Phosphopeptides
  • Controlled release
  • Oral drug delivery
  • Quercetin.

URL: http://benthamscience.com/epub.php?JCode=CDD

Strutture CNR:


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