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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2010

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Trichothecenes NIV and DON modulate the maturation of murine dendritic cells

Anno di pubblicazione: 2010

Formato: Elettronico Cartaceo

Autori: D. Luongo; L. Severino; P. Bergamo; R. D'Arienzo; M. Rossi

Affiliazioni autori: Istituto di Scienze dell'Alimentazione, CNR Department of Pathology and Animal Health, University of Naples Federico II, via F. Delpino 1, 80137 Naples, Italy

Autori CNR:


Lingua: inglese

Abstract: Nivalenol (NIV) and Deoxynivalenol (DON), mycotoxins of the trichothecene family are considered very common food contaminants. In this work, we investigated whether the immunotoxic effects ascribed to these trichothecenes may be mediated by perturbations in the activity of dendritic cells (DCs). Murine bone marrow-derived DCs were used to evaluate the effects of NIV and DON on the LPS-induced maturation process. We found that the expression of the class 11 MHC and of the accessory CD11c molecules, but not of the costimulatory CD86 marker, was down-regulated by NIV and DON exposure in LPS-treated DCs, as well as nitric oxide (NO) production. Interestingly, NIV, but not DON, induced DC necrosis. Moreover, the analysis of the cytokine pattern showed that IL-12 and IL-10 expressions induced by LPS exposure were suppressed by both trichothecenes in a dose-dependent fashion. on the other hand, the secretion of the proinflammatory cytokine TNF-alpha was increased as a direct consequence of DON and NIV exposure. Taken together, our data indicated that the immunotoxicity of NIV and DON was related to the capacity of both trichothecenes to interfere with phenotypic and functional features of maturing DCs. (C) 2009 Elsevier Ltd. All rights reserved.

Lingua abstract: inglese

Pagine da: 73

Pagine a: 80


Toxicon Pergamon,
Paese di pubblicazione: Regno Unito
Lingua: multilingue
ISSN: 0041-0101

Numero volume: 55

Numero fascicolo: 1

DOI: 10.1016/j.toxicon.2009.06.039

Indicizzato da: ISI Web of Science (WOS) [000273921500009]

Strutture CNR:


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