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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2008

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Postprandial chylomicrons and adipose tissue lipoprotein lipase are altered in type 2 diabetes independently of obesity and whole-body insulin resistance

Anno di pubblicazione: 2008

Formato: Elettronico Cartaceo

Autori: Giovanni Annuzzi; Rosalba Giacco; Lidia Patti; Lucrezia Di Marino; Claudia De Natale; Giuseppina Costabile; Maurizio Marra; Carmela Santangelo; Roberta Masella; Angela A. Rivellese

Affiliazioni autori: Department of Clinical and Experimental Medicine, Federico II University, Via Pansini 5, 80131 Naples, Italy Institute of Food Science and Technology, CNR, Avellino, Italy National Centre for Food Quality and Risk Assessment, Istituto Superiore di Sanità, Rome, Italy

Autori CNR:

  • ROSALBA GIACCO

Lingua: inglese

Abstract: BACKGROUND AND AIMS: Postprandial lipoprotein abnormalities in type 2 diabetes are associated with insulin resistance. The role of other diabetes-related factors is still not clear. The aim of this study is to differentiate the effects of whole-body insulin resistance, obesity, and type 2 diabetes on postprandial dyslipidaemia and lipoprotein lipase (LPL) in adipose tissue. METHODS AND RESULTS: Ten subjects with obesity and diabetes (OD), 11 with obesity alone (O), and 11 normal-weight controls (C) - males, aged 26-59 years, with fasting normo-triglyceridaemia underwent measurements of cholesterol, triglycerides, apo B-48 and apo B-100 concentrations in plasma lipoproteins separated by density gradient ultracentrifugation before and after a fat-rich meal. Fasting and postprandial (6h) LPL activity was determined in abdominal subcutaneous adipose tissue biopsy samples. Insulin sensitivity was measured by hyperinsulinaemic euglycaemic clamp. OD and O subjects had similar degrees of adiposity (BMI, waist circumference, fat mass) and insulin resistance (insulin stimulated glucose disposal and M/I). They also showed a similarly higher postprandial increase in large VLDL lipids (triglyceride incremental AUC 188+/-28 and 135+/-22 mg/dl.6h) than C (87+/-13 mg/dl.6h, M+/-SEM, p<0.05). OD had an increased chylomicron response compared to O (triglyceride incremental AUC 132+/-23 vs. 75+/-14 mg/dl.6h, p<0.05). OD had significantly lower fasting and postprandial adipose tissue heparin-releasable LPL activity than O and C. CONCLUSIONS: In insulin-resistant conditions of obesity, with and without diabetes, large VLDL are increased after a fat-rich meal. In addition, diabetic patients compared to obese subjects have an increased postprandial chylomicron response and a reduced adipose tissue LPL activity.

Lingua abstract: inglese

Pagine da: 531

Pagine a: 538

Rivista:

NMCD. Nutrition Metabolism and Cardiovascular Diseases Medikal Press.
Paese di pubblicazione: Italia
Lingua: inglese
ISSN: 0939-4753

Numero volume: 18

Numero fascicolo: 8

DOI: 10.1016/j.numecd.2007.12.003

Referee: Sì: Internazionale

Indicizzato da:

  • ISI Web of Science (WOS) [000260508200003]
  • PubMed [18321693]

Parole chiave:

  • Postprandial lipoproteins
  • Insulin resistance
  • Type 2 diabetes
  • Adipose tissue
  • Lipoprotein lipase

Strutture CNR:

Moduli:

 
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