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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2009

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Sonographic hepatic-renal ratio as indicator of hepatic steatosis: comparison with (1)H magnetic resonance spectroscopy

Anno di pubblicazione: 2009

Formato: Elettronico Cartaceo

Autori: Marcello Mancini; Anna Prinster; Giovanni Annuzzi; Raffaele Liuzzi; Rosalba Giacco; Carmela Medaglie; Matteo Cremone; Gennaro Clemente; Simone Maurea; Gabriele Riccardi; Angela Albarosa Rivellese; Marco Salvatore

Affiliazioni autori: Biostructure and Bioimaging Institute, National Council of Research (CNR), Naples, Italy SDN Foundation, Institute of Diagnostic and Nuclear Development Naples, Italy Department of Clinical and Experimental Medicine, University Federico II, Naples, Italy Institute of Food Science, National Council of Research, Avellino, Italy Department of Biomorphological and Functional Sciences, University Federico II, Naples, Italy

Autori CNR:


Lingua: inglese

Abstract: The aim of this study was to determine the diagnostic performance of ultrasound (US) in the quantitative assessment of steatosis by comparison with proton magnetic resonance spectroscopy (1H-MRS) as a reference standard. Three liver echo-intensity indices were derived: US hepatic mean gray level, hepatic-renal echo-intensity ratio (H/R), and hepatic-portal blood echo-intensity ratio. The 1H-MRS degree of steatosis was determined as percentage fat by wet weight. Regression equations were used to estimate quantitatively hepatic fat content. The hepatic fat content by 1H-MRS analysis ranged from 0.10% to 28.9% (median value, 4.8%). Ultrasound H/R was correlated with the degree of steatosis on 1H-MRS (R2= 0.92; P < .0001), whereas no correlation with 1H-MRS was found for hepatic mean gray level and hepatic-portal blood echo-intensity ratio. A receiver operating characteristic curve identified the H/R of 2.2 as the best cutoff point for the prediction of 1H-MRS of at least 5%, yielding measures of sensitivity and specificity of 100% and 95%, respectively. In this pilot study, US H/R exhibits high sensitivity and specificity for detecting liver fatty changes. Our results indicate that quantitative evaluation of hepatic fat content can be performed using US H/R and could therefore be a valuable analytic tool in clinical investigation.

Lingua abstract: inglese

Pagine da: 1724

Pagine a: 1730


Metabolism, clinical and experimental W.B. Saunders Co. [etc.]
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 0026-0495

Numero volume: 58

Numero fascicolo: 12

DOI: 10.1016/j.metabol.2009.05.032

Referee: Sė: Internazionale

Strutture CNR:

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