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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2008

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Cytotoxic and apoptogenic activity of a methanolic extract from the marine invertebrate Ciona intestinalis on malignant cell lines.

Anno di pubblicazione: 2008

Formato: Cartaceo

Autori: Russo GL, Ciarcia G, Presidente E, Siciliano RA, Tosti E.

Affiliazioni autori: Stazione Zoologica “Anton Dohrn”, 80121, Napoli, Italy Institute of Food Sciences, National Research Council,83100, Avellino, Italy Department of Biology, Section of Zoology, University of Naples “Federico II”, 80124, Napoli,Italy

Autori CNR:

  • GIAN LUIGI RUSSO
  • ROSA ANNA SICILIANO

Lingua: inglese

Abstract: Marine invertebrates provide a series of natural products with different biological activities. Several of these compounds and their derivatives showed a potent anticancer effect. Tunicates represent an important source of bioactive agents, leading to the isolation of ecteinascidin-743 (ET-743), a compound isolated from the Caribbean sea squirt Ecteinascidia turbinata with a potent cytotoxic activity against a variety of tumours in vitro and in vivo. Current phase II clinical trials against soft tissue sarcomas in Europe and the United States indicate that ET-743 represents a highly promising anticancer agent. Another example is aplidine from the Mediterranean tunicate Aplidium albicans, with a broad spectrum activity against various types of cancers, such as colorectal, lymphoma, thyroid and renal cancers. In the present work, we reported, for the first time, that a partially purified methanolic extract prepared from the ascidian Ciona intestinalis inhibited cell proliferation in human cell lines of different origin, including Caco2, HPB-ALL, U-937 and HL-60 and induced early apoptotic events, such as caspase-3 activation and internucleosomal DNA degradation. We suggest the presence in the Ciona intestinalis extract of bioactive compounds possessing anticancer activity.

Lingua abstract: inglese

Pagine da: 106

Pagine a: 109

Rivista:

Medicinal chemistry Bentham Science Publishers
Paese di pubblicazione: Paesi Bassi
Lingua: inglese
ISSN: 1573-4064

Numero volume: 4

Numero fascicolo: 2

Referee: Sì: Internazionale

Indicizzato da: PubMed [18336328]

Parole chiave:

  • apoptosis
  • cytotoxicity
  • tunicate
  • ascidian

Strutture CNR:

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