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Contributo in rivista
Tipo: Articolo in rivista
Titolo: Cytotoxic and apoptogenic activity of a methanolic extract from the marine invertebrate Ciona intestinalis on malignant cell lines.
Anno di pubblicazione: 2008
Autori: Russo GL, Ciarcia G, Presidente E, Siciliano RA, Tosti E.
Affiliazioni autori: Stazione Zoologica “Anton Dohrn”, 80121, Napoli, Italy Institute of Food Sciences, National Research Council,83100, Avellino, Italy Department of Biology, Section of Zoology, University of Naples “Federico II”, 80124, Napoli,Italy
Abstract: Marine invertebrates provide a series of natural products with different biological activities. Several of these compounds and their derivatives showed a potent anticancer effect. Tunicates represent an important source of bioactive agents, leading to the isolation of ecteinascidin-743 (ET-743), a compound isolated from the Caribbean sea squirt Ecteinascidia turbinata with a potent cytotoxic activity against a variety of tumours in vitro and in vivo. Current phase II clinical trials against soft tissue sarcomas in Europe and the United States indicate that ET-743 represents a highly promising anticancer agent. Another example is aplidine from the Mediterranean tunicate Aplidium albicans, with a broad spectrum activity against various types of cancers, such as colorectal, lymphoma, thyroid and renal cancers. In the present work, we reported, for the first time, that a partially purified methanolic extract prepared from the ascidian Ciona intestinalis inhibited cell proliferation in human cell lines of different origin, including Caco2, HPB-ALL, U-937 and HL-60 and induced early apoptotic events, such as caspase-3 activation and internucleosomal DNA degradation. We suggest the presence in the Ciona intestinalis extract of bioactive compounds possessing anticancer activity.
Lingua abstract: inglese
Pagine da: 106
Pagine a: 109
Bentham Science Publishers
Numero volume: 4
Numero fascicolo: 2
Referee: Sì: Internazionale
Indicizzato da: PubMed 
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