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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2010

Contributo in rivista

Tipo: Articolo in rivista

Titolo: A sensitive period for environmental regulation of eating behavior and leptin sensitivity

Anno di pubblicazione: 2010

Formato: Elettronico Cartaceo

Autori: Mainardi M, Scabia G, Vottari T, Santini F, Pinchera A, Maffei L, Pizzorusso T, Maffei M.

Affiliazioni autori: Scuola Normale Superiore Pisa (Mainardi, Maffei L) Istituto Neuroscienze CNR (Pizzorusso , Maffei L) Dulbecco Telethon Institute (Maffei M, Scabia) Dipartimento di Endocrinologia e Metabolismo, Università di Pisa (Pinchera, Santini) ISA CNR (Maffei M)

Autori CNR:

  • LAMBERTO MAFFEI
  • MARGHERITA MAFFEI
  • TOMMASO PIZZORUSSO

Lingua: inglese

Abstract: Western lifestyle contributes to body weight dysregulation. Leptin down-regulates food intake by modulating the activity of neural circuits in the hypothalamic arcuate nucleus (ARC), and resistance to this hormone constitutes a permissive condition for obesity. Physical exercise modulates leptin sensitivity in diet-induced obese rats. The role of other lifestyle components in modulating leptin sensitivity remains elusive. Environmentally enriched mice were used to explore the effects of lifestyle change on leptin production/action and other metabolic parameters. We analyzed adult mice exposed to environmental enrichment (EE), which showed decreased leptin, reduced adipose mass, and increased food intake. We also analyzed 50-d-old mice exposed to either EE (YEE) or physical exercise (YW) since birth, both of which showed decreased leptin. YEE mice showed no change in food intake, increased response to leptin administration, increased activation of STAT3 in the ARC. The YW leptin-induced food intake response was intermediate between young mice kept in standard conditions and YEE. YEE exhibited increased and decreased ratios of excitatory/inhibitory synapses onto ?-melanocyte-stimulating hormone and agouti-related peptide neurons of the ARC, respectively. We also analyzed animals as described for YEE and then placed in standard cages for 1 mo. They showed no altered leptin production/action but demonstrated changes in excitatory/inhibitory synaptic contacts in the ARC similar to YEE. EE and physical activity resulted in improved insulin sensitivity. In conclusion, EE and physical activity had an impact on feeding behavior, leptin production/action, and insulin sensitivity, and EE affected ARC circuitry. The leptin-hypothalamic axis is maximally enhanced if environmental stimulation is applied during development.

Lingua abstract: inglese

Pagine da: 16673

Pagine a: 16678

Pagine totali: 6

Rivista:

Proceedings of the National Academy of Sciences of the United States of America The Academy,
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 0027-8424

Numero volume: 107

DOI: 10.1073/pnas.0911832107

Referee: Sì: Internazionale

Indicizzato da: ISI Web of Science (WOS) [000282003700053]

Parole chiave:

  • environmental enrichment
  • arcuate nucleus
  • AgRP
  • POMC
  • synaptic plasticity

URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944733/

Strutture CNR:

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Allegati: Articolo pubblicato (application/pdf)

 
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