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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2008

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Genetic variants of Y chromosome are associated with a protective lipid profile in black men

Anno di pubblicazione: 2008

Formato: Elettronico

Autori: Russo P.; Siani A.; Miller M.A.; Karanam S.; Esposito T.; Gianfrancesco F.; Barba G.; Lauria F.; Strazzullo P.; Cappuccio F.P.

Affiliazioni autori: Unit of Epidemiology and Population Genetics, Institute of Food Sciences, CNR, Via Roma, 64-83100 Avellino, Italy; Clinical Science Research Institute, University of Warwick Medical School, Coventry, UK; Institute of Genetics and Biophysics "Adriano Buzzati-Traverso" (T.E., F.G.), CNR, Naples, Italy;Department of Clinical & Experimental Medicine, University of Naples "Federico II", Naples, Italy.

Autori CNR:

  • GIANVINCENZO BARBA
  • TERESA ESPOSITO
  • FERNANDO GIANFRANCESCO
  • FABIO LAURIA
  • PAOLA RUSSO
  • ALFONSO SIANI

Lingua: inglese

Abstract: OBJECTIVE: Gender and ethnicity modulate the phenotypic expression of cardiovascular risk factors. In particular, men are at higher risk of developing cardiovascular diseases compared to women, whereas black populations of African origin display reduced mortality from coronary heart disease (CHD) as compared to both whites and South Asians. Because the male-specific region (MSY) of the human Y chromosome is an obvious candidate for gender-related differences in the development of cardiovascular diseases, we aimed to identify genetic variants of MSY influencing cardiovascular risk profile in different ethnic groups. METHODS AND RESULTS: We genotyped 4 polymorphisms of MSY (HindIII+/-, rs768983 of TBL1Y, rs3212292 of USP9Y, and rs9341273 of UTY genes) in 579 men of different ethnic groups (blacks, South Asians, and whites) from UK and in 301 whites in Italy. We found that the TBL1Y(A) USP9Y(A) haplotype, present only in blacks in whom it represents the most frequent allelic combinations (AA: n=125; all other combinations: n=45), was associated with lower levels of triglycerides (P=0.025) and higher levels of HDL-cholesterol (P=0.005) as compared to the other haplotypes. CONCLUSIONS: The TBL1Y(A) USP9Y(A) haplotype of the Y chromosome, present only in black people of African origin, attributes a favorable lipoprotein pattern, likely to contribute to their reduced susceptibility to coronary heart disease

Lingua abstract: inglese

Pagine da: 1569

Pagine a: 1574

Rivista:

Arteriosclerosis, thrombosis, and vascular biology HighWire Press,
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 1524-4636

Numero volume: 28

Numero fascicolo: 8

DOI: 10.1161/ATVBAHA.108.168641

Referee: Sė: Internazionale

Indicizzato da: ISI Web of Science (WOS) [000257880100025]

Parole chiave:

  • Y chromosome
  • cardiovascular risk
  • lipoprotein
  • ethnicity
  • male

Strutture CNR:

Moduli:

Allegati: Articolo pubblicato (application/pdf)

 
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