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Contributo in rivista
Tipo: Articolo in rivista
Titolo: Dietary phytochemicals in chemoprevention of cancer.
Anno di pubblicazione: 2005
Autori: Russo, M.; Tedesco, I.; Iacomino, G.; Palumbo, R.; Galano, G.; Russo, G. L.
Affiliazioni autori: CNR; CNR; CNR; CNR; CNR; CNR;
Abstract: Regular consumption of fruit and vegetables is assocd. with reduced risks of cancer, cardiovascular disease and other aging-related diseases. Convincing evidence exists suggesting that an increased fruit, vegetables, and grains consumption is a relatively easy and practical strategy to significantly reduce the incidence of chronic diseases. Cancer chemoprevention intends to interrupt the carcinogenesis process, which includes initiation, promotion and progression of otherwise normal cells to reduce cancer. Despite the failure of b-carotene clin. trial to prevent lung cancer, the development of diet-derived constituents represents one of the major goal in cancer chemoprevention. A key question is whether a purified phytochem. has the same protective effects as does the whole food or mixt. of foods in which the phytochem. is present. Putative chemopreventive agents are identified on the basis of epidemiol. and in vitro and in vivo studies. All these compds. present tumor-suppressing properties in animal models of carcinogenesis, and they interfere with cellular processes involved in tumor formation, such as suppression of NF-kB and AP1 activation, induction of apoptosis, downregulation of b-catenin expression and activation of ARE/EpRE-dependent gene expression. Phase I clin. trials have been completed only for few of these phytochems., and pilot phase II-III trials are planned. In this review, we will begin by describing the different methodol. approaches in studying chemopreventive agents, followed by the description of the mechanisms by which these compds. act. Finally, we will review more in details data concerning well-known and promising chemopreventive phytochems.
Lingua abstract: inglese
Pagine da: 61
Pagine a: 72
Current medicinal chemistry
Bentham Science Publishers
Numero volume: 5
Indicizzato da: Scopus [2-s2.0-13844276223]
Altre informazioni: 2
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