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Istituto di scienza dell'alimentazione

Torna all'elenco Libri anno 2008

Libro

Tipo: Monografia o trattato scientifico

Titolo: Regulatory T-cells in the celiac intestinal mucosa: a new perspective for treatment?

Anno di pubblicazione: 2008

Formato: Cartaceo

Autori: Gianfrani C, Camarca A, Salvati V, Mazzarella G, Roncarolo MG and Troncone R.

Affiliazioni autori: Institute of Food Sciences, CNR Avellino, Avellino, Department of Paediatrics and European Laboratory for the Investigation of Food-Induced Diseases, University Federico II, Naples San Raffaele Telethon Institute of Gene Therapy, San Raffaele Scientific Institute Milan, Milan, Italy

Autori CNR:

  • CARMELA GIANFRANI
  • GIUSEPPE MAZZARELLA

Lingua: inglese

Sintesi: In the physiological condition, the immune system tolerizes the huge amount of proteins that are daily introduced into the gastro-intestinal tract with the diet, a phenomenon known as oral tolerance. Many and complex immunological mechanisms are involved in the induction of oral tolerance including suppression by regulatory T cells (Treg). In addition, a key role in the gut homoeostasis is sustained by immunosuppressive cytokines, such as interleukin (IL)-10 and transforming growth factor (TGF) , released by Treg. Coeliac disease is a common, and almost worldwide spread, intolerance to wheat gluten and related proteins from barley and rye. Coeliac disease is caused by abnormal pro-inflammatory responses to ingested gluten in which gliadin-reactive T cells are one of the main actors in orchestrating the complex adverse immune reactions following gluten ingestion. Our recent studies have revealed that the treatment with IL-10 of small-intestinal mucosa from coeliac disease patients in remission prevents the massive immune activation induced by gluten challenge. Furthermore, we have observed that coeliac intestinal mucosa harbours a subset of Treg, the Tr1, that through the release of both IL-10 and TGF- inhibit the pathogenic response to in vitro gluten challenge. Herein we discuss these recent studies on Treg in coeliac disease mucosa and envision an IL-10-based therapeutic approach for coeliac disease.

Pagine da: 181

Pagine a: 187

Pagine totali: 7

N. volume della serie/collana: Vol 12

Curatore/i del volume: Editori: A. Fasano, D. Branski, R. Troncone

ISBN: 978-3-8055-8526-2

Editore: Karger, Basel (SWZ)

Referee: Sì: Internazionale

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