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Istituto sull'inquinamento atmosferico

Torna all'elenco Contributi in rivista anno 2017

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Pharmaceutical substances in ambient particulates: A preliminary assessment

Anno di pubblicazione: 2017

Formato: Elettronico

Autori: Cecinato A.; Romagnoli P.; Perilli M.; Balducci C.

Affiliazioni autori: National Research Council of Italy, Institute of Atmospheric Pollution Research (CNR-IIA), via Salaria, km 29.3, P. O. Box 10, Monterotondo RM, 00015, , Italy

Autori CNR:

  • CATIA BALDUCCI
  • ANGELO CECINATO
  • MATTIA PERILLI
  • PAOLA ROMAGNOLI

Lingua: inglese

Abstract: Till now, no attention has been paid to pharmaceuticals (PCs) in the air, though they are known to affect waters, soils, foods and biota. This paper describes the first attempt to characterize the PC occurrence in the air. Airborne particulates (PM10 or PM2.5 fractions, from Amsterdam, Netherland, Rome and Rende, Italy) were sampled on quartz fiber filter by means of pumping systems operating at medium-volume conditions (16 or 38.5 L min1). The samples were solvent extracted through sonication with a dichloromethane:acetone:methanol mixture and reduced close to dryness; three fractions of the residue were separated through column chromatography; they comprised non polar, low polar and very polar organic compounds, respectively, and PCs were in the third one. Chemical analysis was performed by means of gas chromatography coupled with mass spectrometric detection (GC-MSD), after treatment of solutions with methyl,tertzbutylsilyl-trifluoroacetamide (MTBSTFA) to form silyl derivatives of most PCs. The following substances were investigated: acetaminophenol, ibuprofen, ketoprofen, fenoprefen, naproxen, fenofibrate, diclofenac, acetylcysteine and sulfanilamide; p-hydroxybenzoic acid and salicylic acid; and parabens (methyl, ethyl and propyl). Except aspirin, acetamidophenol, acetylcysteine and sulfanilamide, the target compounds could be quantified with good repeatability, reproducibility and percent recoveries (on the average, ~7.5%, ~7.1% and 91%, respectively). The PC concentrations ranged <0.1 e8.6 ng m3; season dependent drug profiles could be observed in Rome and Rende.

Lingua abstract: inglese

Pagine da: 62

Pagine a: 68

Rivista:

Chemosphere Elsevier
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 0045-6535

Numero volume: 183

DOI: 10.1016/j.chemosphere.2017.05.100

Referee: Sė: Nazionale

Stato della pubblicazione: Published version

Indicizzato da: Scopus [2-s2.0-85019922162]

Parole chiave:

  • Airborne particulates
  • GC-MSD analysis
  • Pharmaceuticals
  • Methyl
  • tertzbutylsilyl-trifluoroacetamide (MTBSTFA)
  • Environmental contaminants

URL: http://www.scopus.com/record/display.url?eid=2-s2.0-85019922162&origin=inward

Strutture CNR:

 
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